Increased Intestinal Permeability and Parkinson Disease Patients: Chicken or Egg?
Identifieur interne : 001516 ( Main/Exploration ); précédent : 001515; suivant : 001517Increased Intestinal Permeability and Parkinson Disease Patients: Chicken or Egg?
Auteurs : D. Salat-Foix [Canada] ; K. Tran [Canada] ; R. Ranawaya [Canada] ; J. Meddings [Canada] ; O. Suchowersky [Canada]Source :
- Canadian journal of neurological sciences [ 0317-1671 ] ; 2012.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Chicken, Female, Human, Humans, Intestinal Absorption (physiology), Intestinal Mucosa (metabolism), Intestinal disease, Intestines (metabolism), Lactulose (metabolism), Male, Mannitol (metabolism), Middle Aged, Nervous system diseases, Parkinson Disease (metabolism), Parkinson disease, Permeability, Sucrose (metabolism).
- MESH :
- chemical , metabolism : Lactulose, Mannitol, Sucrose.
- metabolism : Intestinal Mucosa, Intestines, Parkinson Disease.
- physiology : Intestinal Absorption.
- Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Permeability.
Abstract
L'atteinte gastro-intestinale est fréquente et précoce dans l'évolution de la maladie de Parkinson (MP) et pourrait jouer un rôle important tôt dans la physiopathologie de la maladie. D'autre part, l'altération de la perméabilité intestinale pourrait également être due à une atteinte du tractus gastro-intestinal au cours de l'évolution de la maladie. Méthode: Nous avons étudié la perméabilité intestinale de 12 patients atteints de la MP, choisis au hasard, au moyen d'un test validé non effractif. Nous avons comparé leurs résultats à des valeurs de référence préétablies ajustées pour l'âge. Résultats: La perméabilité gastro-intestinale était anormale chez 4 des 12 patients. Deux avaient un rapport lactulose/mannitol anormal et une concentration de sucrose anormale et 2 avaient un résultat anormal isolé. Une augmentation du rapport lactulose/mannitol est en faveur d'un défaut soit des entérocytes ou des jonctions serrées entre eux. Conclusion: La perméabilité intestinale est augmentée chez une proportion importante de patients atteints de la MP, choisis au hasard, qui ont peu de symptômes gastro-intestinaux. La signification de cette observation mérite d'être étudiée davantage.
Affiliations:
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Le document en format XML
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<front><div type="abstract" xml:lang="fr">L'atteinte gastro-intestinale est fréquente et précoce dans l'évolution de la maladie de Parkinson (MP) et pourrait jouer un rôle important tôt dans la physiopathologie de la maladie. D'autre part, l'altération de la perméabilité intestinale pourrait également être due à une atteinte du tractus gastro-intestinal au cours de l'évolution de la maladie. Méthode: Nous avons étudié la perméabilité intestinale de 12 patients atteints de la MP, choisis au hasard, au moyen d'un test validé non effractif. Nous avons comparé leurs résultats à des valeurs de référence préétablies ajustées pour l'âge. Résultats: La perméabilité gastro-intestinale était anormale chez 4 des 12 patients. Deux avaient un rapport lactulose/mannitol anormal et une concentration de sucrose anormale et 2 avaient un résultat anormal isolé. Une augmentation du rapport lactulose/mannitol est en faveur d'un défaut soit des entérocytes ou des jonctions serrées entre eux. Conclusion: La perméabilité intestinale est augmentée chez une proportion importante de patients atteints de la MP, choisis au hasard, qui ont peu de symptômes gastro-intestinaux. La signification de cette observation mérite d'être étudiée davantage.</div>
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